Off the grid
Layout design is such an important element of design that you don't even realize it is there. A good layout is what can ultimately make or break an entire design. It's the same as where you set the furniture at your home, that is what makes the room look good and spaces everything out.
The layout of the website for example should be in accordance with the relevant topic and expectations of the visitors. This is where the graphic design should support the content to showcase it in the best light possible.